Recombinant Human TNFSF15/TL1 Protein

< 1.0 EU/μg of the protein by LAL method.

ice pack

20.47 kDa

The protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

No tag

TL1, TL1A, TNLG1B, VEGI, VEGI192A

1. Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 Protein at 5 μg/mL (100 μL/well) can bind DCR3 with a linear range of 0. 12-6. 98 ng/mL.|2. Measured by its ability to induce apoptosis of TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is 52. 1-208. 5 ng/mL, corresponding to a specific activity of 4. 79×10³~1. 92×10⁴ units/mg.

20.47 kDa