Recombinant Human CD46 Protein

< 0.1 EU/μg of the protein by LAL method.

ice pack

33.62 kDa

The recombinant human CD46 consists of 305 amino acids with a molecular weight of 34 kDa. The apparent molecular mass of recombinant human CD46 is about 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.CD46 is also known as MCP and is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. In T-cells by binding to CD46, A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2), a disease characterized by uncontrolled complement activation.

C-His

AHUS2 , MCP , MIC10 , TLX , TRA2.10

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation.

CD46