Anti-Adiponectin Receptor 1 Antibody - Carrier Free

Antibodies

Israel

Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

AdipoR1, Progestin And AdipoQ Receptor Family Member 1, PAQR1 - A rabbit polyclonal antibody to Adiponectin Receptor 1

Rat, human – 13 out of 14 amino acids identical.

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

7, 4

Adiponectin receptor 1 (Adipor1) is a crucial component of the cellular machinery that mediates the metabolic and anti-inflammatory effects of the adipokine adiponectin._x000D_ AdipoR1 is part of the PAQR (Progestin and AdipoQ Receptor) family, that is characterized by a seven-transmembrane domain organization with intracellular N-terminus and extracellular C-terminus, which is the reverse topology of the seven-transmembrane topology of G-protein coupled receptors.1, 2_x000D_ Adiponectin is a hormone primarily secreted by adipose (fat) tissue. It plays a crucial role in regulating glucose levels as well as fatty acid breakdown. Adiponectin is also involved in reducing inflammation and improving insulin sensitivity, making it an important factor in metabolic health. AdipoR1 and its paralog AdipoR2, mediate the effects of adiponectin, together with Cadherin-13, also known as T-cadherin (CDH13). Unlike AdipoR1 and AdipoR2, Cadherin-13 is a glycosylphosphatidylinositol (GPI)-anchored protein that lacks a transmembrane domain. It acts as a non-signaling co-receptor for the hexameric and high-molecular-weight forms of adiponectin, especially in cardiovascular tissues.2, 3, 4_x000D_ Adipor1 is expressed across a wide range of tissues, reflecting its systemic metabolic role. It is most abundantly expressed in skeletal muscle, a major site for glucose uptake and fatty acid oxidation. It is also present in the liver, heart, adipose tissue, kidneys, and notably, the central nervous system (CNS). This broad expression pattern enables Adipor1 to influence diverse physiological processes from peripheral glucose metabolism to central neuroregulation.2, 3_x000D_ Adipor1 primarily acts as a receptor for both full-length and globular forms of adiponectin. Upon ligand binding, it activates downstream signaling pathways, including AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARα). These pathways enhance insulin sensitivity, promote fatty acid oxidation, and inhibit gluconeogenesis, thereby contributing to improved glucose metabolism and lipid balance.2, 3_x000D_ In the CNS, AdipoR1 is expressed in various areas of the brain, including the hypothalamus, brainstem, hippocampus, and cortex, regions that are involved in regulating energy homeostasis, cognitive function, and motor coordination.5, 6_x000D_  In the hypothalamus and brainstem, adiponectin is thought to regulate food intake and energy expenditure via AdipoR1-mediated AMP-activated protein kinase (AMPK) signaling, while in the hippocampus Adipor1 has been implicated in cognitive functions such as learning and memory.5, 6_x000D_ Finally, it was found that decreased AdipoR1 expression causes spatial learning and memory impairment and Alzheimer’s disease-like pathologies, thus suggesting that the adiponectin-AdipoR1 axis should be considered as a treatment target for Alzheimer’s disease, as well as other neurodegenerative disorders.5, 6, 7