GGPS1, 1-300aa, Human, His tag, E.coli

Geranylgeranyl pyrophosphate synthase isoform A, also known as GGPS1, is a member of the prenyltransferase family. Predominantly expressed in testis, heart and skeletal muscle, GGPS1 localizes to the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate, a precursor of geranylgeranylated proteins and carotenoids. GGPS1 is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Recombinant human GGPS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

1mg/ml (determined by Bradford assay)

• Okada K., et al. (2000) Plant Physiol. 122:1045-1056.
• Kainou T., et al. (1999) Biochem Biophys. 1437:330-340.

>, 90% by SDS - PAGE

MGSSHHHHHH SSGLVPRGSH MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLDHPD AVKLFTRQLL ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLNTL GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN IDIKKYCVHY LEDVGSFEYT RNTLKELEAK AYKQIDARGG NPELVALVKH LSKMFKEENE