Beta-Amyloid (11-40), FAM-labeled

beta-amyloid, beta-amyloid (X-40)

RT

3510.2

This Abeta peptide (11-40) is FAM-labeled (Abs/Em=494/521 nm). FAM is preferred over FITC because of its photo- and chemical stability.
Post-mortem Alzheimer’s diseased brain specimens reveal significant levels of Aß (11-40/42) within insoluble amyloid pools. The ß-secretase enzyme or ß-amyloid precursor protein-cleaving enzyme (BACE) generates the N terminus of Aß, ultimately leading to the production of full-length Aß (1-40/42) or truncated Aß (11-40/42). The abundance of Aß (11-40/42) produced by BACE suggests that their roles in AD pathogenesis may be important.

521

Fluorescent

Research use

5400535147839