MMP-1 (Catalytic Domain), human recombinant

Catalog recombinant

Catalog Recombinant Proteins / Catalog Recombinant / Proteins

Dry Ice

17.5 kDa

Matrix metalloproteinases (MMP’s) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-1 (collagenase-1) is involved in tumor development and metastasis and rheumatoid arthritis. It is proposed as a therapeutic target for these diseases. MMP-1 digests a broad range of substrates, including ?-1 antitrypsin, myelin basic protein, collagen I, II, III, VII, VIII, casein, gelatin, and others - The sequence (Accession # NP_002412) corresponding to the catalytic domain (aa 106-261) of Human MMP-1 was expressed in E. coli. The recombinant human MMP-1 was purified from bacterial lysate and refolded using proprietary technique. The molecular weight of the recombinant Human MMP-1 Catalytic Domain is ~17.5 kDa.

lot dependent

Catalytic domain (aa 106-261) of Human MMP-1

Research use

5400535007157