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Caspase 3 (Apopain) Substrate 1m, fluorogenic - 5 mg

Caspase 3 (Apopain) Substrate 1m, fluorogenic - 5 mg

ArtNr	AS-25262-5
Hersteller	AnaSpec
Menge	5 mg
Kategorie	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Cell Biology Cell Status Apoptosis Reagents & Chemicals Staining & Dyes Fluorescent Reagents
Typ	Fluorescent dyes and probes
Format	Lyophilized
Specific against	other
Purity	Peak Area by HPLC ≥95%
Sequence	Ac-Asp-Glu-Val-Asp-AMC
Citations	Koeplinger KA, et al. (2000). Caspase 8: an efficient method for large-scale autoactivation of recombinant procaspase 8 by matrix adsorption and characterization of the active enzyme. Protein Expr Purif 18, 378-87; Garcia-Calvo M, et al. (1998). Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273, 32608-13; Thornberry NA, et al. (1997). A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272, 17907-11; Rano TA, et al. (1997). A combinatorial approach for determining protease specificities: application to interleukin-1 beta converting enzyme (ICE). Chem Biol 4, 149-55; Margolin N, et al. (1997). Substrate and inhibitor specificity of interleukin-1 ?-converting enzyme and related caspases. J Biol Chem 272, 7223-8; Mizushima N, et al. (1996). Ceramide induces apoptosis via CPP32 activation. FEBS Lett 395, 267-71; Faubion WA, et al. (1999). Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 103, 137-45.
ECLASS 10.1	30196090
ECLASS 11.0	30196090
UNSPSC	12000000
Alias	Ac-DEVD-AMC
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Catalog
Manufacturer - Applications	FRET; Protease activity
Manufacturer - Category	Peptides
Manufacturer - Targets	Caspase; Caspase 3
Manufacturer - Conjugate / Tag	AMC
Shipping Temperature	RT
Storage Conditions	- 20 °C Protected from light
Molecular Weight	675.7
Description	AMC (7-amino-4-methylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AMC peptides by caspases generates strongly fluorescent AMC that is monitored fluorimetrically at 440-460 nm with excitation of 340-350 nm.
Product Group	LB1A3Z
Research Area	Cancer & Apoptosis; Cell Signaling / Lyophilized
Absorbtion (nm)	350
Emission (nm)	440
Sequence One-Letter Code	Ac-DEVD-AMC
GTIN	5400535038540
Detection Method	Fluorescent
Usage	Research use
UNSPSC	12352202

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AS-25262-5-safety-datasheet.pdf