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Caspase 3 (Apopain) Substrate 1m, fluorogenic - 5 mg

Caspase 3 (Apopain) Substrate 1m, fluorogenic - 5 mg

Item no.	AS-25262-5
Manufacturer	AnaSpec
Amount	5 mg
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Cell Biology Cell Status Apoptosis Reagents & Chemicals Staining & Dyes Fluorescent Reagents
Type	Fluorescent dyes and probes
Format	Lyophilized
Specific against	other
Purity	Peak Area by HPLC ≥95%
Sequence	Ac-Asp-Glu-Val-Asp-AMC
Citations	Koeplinger KA, et al. (2000). Caspase 8: an efficient method for large-scale autoactivation of recombinant procaspase 8 by matrix adsorption and characterization of the active enzyme. Protein Expr Purif 18, 378-87; Garcia-Calvo M, et al. (1998). Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273, 32608-13; Thornberry NA, et al. (1997). A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272, 17907-11; Rano TA, et al. (1997). A combinatorial approach for determining protease specificities: application to interleukin-1 beta converting enzyme (ICE). Chem Biol 4, 149-55; Margolin N, et al. (1997). Substrate and inhibitor specificity of interleukin-1 ?-converting enzyme and related caspases. J Biol Chem 272, 7223-8; Mizushima N, et al. (1996). Ceramide induces apoptosis via CPP32 activation. FEBS Lett 395, 267-71; Faubion WA, et al. (1999). Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 103, 137-45.
ECLASS 10.1	30196090
ECLASS 11.0	30196090
UNSPSC	12000000
Alias	Ac-DEVD-AMC
Shipping Condition	Room temperature
Available
Manufacturer - Type	Catalog
Manufacturer - Applications	FRET; Protease activity
Manufacturer - Category	Peptides
Manufacturer - Targets	Caspase; Caspase 3
Manufacturer - Conjugate / Tag	AMC
Shipping Temperature	RT
Storage Conditions	- 20 °C Protected from light
Molecular Weight	675.7
Description	AMC (7-amino-4-methylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AMC peptides by caspases generates strongly fluorescent AMC that is monitored fluorimetrically at 440-460 nm with excitation of 340-350 nm.
Product Group	LB1A3Z
Research Area	Cancer & Apoptosis; Cell Signaling / Lyophilized
Absorbtion (nm)	350
Emission (nm)	440
Sequence One-Letter Code	Ac-DEVD-AMC
GTIN	5400535038540
Detection Method	Fluorescent
Usage	Research use
UNSPSC	12352202

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AS-25262-5-safety-datasheet.pdf