Mouse Monoclonal Antibody to C-Kit

Mouse IgG1

MW: 145kDa
Enterez GeneID: 3815
General Information: C-kit (CD117, 145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.
Immunogen: Purified recombinant fragment of C-kit expressed in E. Coli.
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000
References: 1. Svenningsson P, Greengard P. Curr Opin Pharmacol. 2007; 7(1):27-32. ; 2. Santamaria-Kisiel L, Rintala-Dempsey AC, Shaw GS. Biochem J. 2006; 396(2):201-14. ; 3. Rust R, VL, van dJ, Harms G, .et al. Br J Haematol. 2005; 131(5):596-608. ;