Mouse Monoclonal Antibody to HLA-DRA

Mouse IgG2b

MW: 58.8kDa
Enterez GeneID: 3858
General Information: HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. ;
Immunogen: Purified recombinant fragment of human HLA-DRA (AA: 26-254) expressed in E. Coli.
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: ; ICC: 1 to 100 - 1 to 500; FCM: 1 to 200 - 1 to 400
References: 1.Breast Cancer Res. 2015 Sep 17; 17:127. ; 2.J Cancer Res Clin Oncol. 2014 Sep; 140(9):1625-8.;