GPCR Ligand Screening related services & products

GPCR Ligand Screening Related Services/Products

INTRODUCTION
The G protein-coupled receptor (GPCR) gene superfamily consists of hundreds of members that are widely expressed in all tissues and serve as receptors for a diverse complement of ligands. Approximately 100 of these receptors are considered orphan GPCRs, in that no endogenous ligand has been confirmed for them.
Characterized by having seven transmembrane alpha-helical domains, GPCRs mediate a wide spectrum of cellular processes ranging from cell growth to neurotransmission. On activation via ligand binding, GPCRs couple to heterotrimeric G proteins composed of three subunits: Ga, b and g