Anti-GOLGB1 (Giantin) Antibody

Primary Antibody

Giantin

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.

200 µg/mL

ICC

Our Anti-GOLGB1 (Giantin) chicken polyclonal primary antibody from Aves Labs is produced in-house. It detects human GOLGB1 (Giantin), and is affinity-purified IgY. It is great for use in IHC and ICC.

GOLGB1, also known as Giantin, is a protein associated with the Golgi
apparatus, playing a key role in maintaining its structural integrity
and facilitating vesicle trafficking between the endoplasmic reticulum
and the Golgi. Discovered within the context of Golgi apparatus research
initiated by Camillo Golgi in 1898, the molecular cloning and
sequencing of the GOLGB1 gene in the early 1990s allowed detailed
studies of its structure and function, revealing its role in stacking
Golgi cisternae and influencing various cell signaling pathways.
Functional studies, including knockdown and knockout experiments (Satoh
et al 2019), have demonstrated GOLGB1’s importance in maintaining Golgi
integrity. A myriad of diseases are associated with Golgi dysfunction,
including neurodegenerative diseases such as ALS, Alzheimer’s, and
Parkinson’s, as well as cancer and congenital disorders of glycosylation
(Lan etc al, 2016). In time, GOLGB1 (Giantin) could potentially serve
as a therapeutic target for many of these conditions.

Polyclonal

1:100-1:500

Human

Affinity-Purified IgY

Yes

Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification