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Klotho Antibody (C-term) [APR08109G]

Klotho Antibody (C-term) [APR08109G]

ArtNr	LBI-APR08109G
Hersteller	Leading Biology
Menge	100 ul
Quantity options	100 ul
Kategorie	Metabolism Diabetes Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Klotho, 3.2.1.31, Klotho peptide, KL
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Manufacturer - Type	Polyclonal Antibodies
Manufacturer - Category	Abs-G
Storage Conditions	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Molecular Weight	116181
Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Klotho Antibody (C-term) [APR08109G].
Manufacturer - Specificity	This Klotho antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 284-315 amino acids from the C-terminal region of human Klotho.
Cellular localization	[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250\|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000250\|UniProtKB:O35082} [Klotho peptide]: Secreted {ECO:0000250\|UniProtKB:O35082}
Gene Name	KL
Function	May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
Summary	Tissue Location: Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid Expressed in kidney, placenta, small intestine and prostate. Down- regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.
Dilution	WB-1:2000
Clonality	Polyclonal

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100 ul

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Lieferung vsl. bis 16.10.2025

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