STAMBP Antibody

ArtNr	OACA03732-100UG
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Neuroinflammation Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Adenocarcinoma Mesothelioma Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Cardiovascular Research Proliferation Myocardial Infarction Primary Antibodies Astrocytoma By Organ Bladder Cancer Immunostaining
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	[1]"Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome."FORGE Canada ConsortiumMcDonell L.M., Mirzaa G.M., Alcantara D., Schwartzentruber J., Carter M.T., Lee L.J., Clericuzio C.L., Graham J.M. Jr.,
Alias	AMSH;associated molecule with the SH3 domain of STAM;endosome-associated ubiquitin isopeptidase;MICCAP;STAM-binding protein;testicular secretory protein Li 54.
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Gene symbol	STAMBP
Gene Fullname	STAM binding protein
Product format	Liquid
Reconstitution and storage	-20°C or -80°C
Description of target	Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.
Nucleotide accession_num	NM_006463
Protein accession_num	NP_006454
Protein name	STAM-binding protein
Clonality	Polyclonal
Purification	Protein G Purified
Immunogen	Recombinant Human STAM-binding protein (1-424AA)

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OACA03732-100UG-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 25.12.2025

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