BCL7C (B-Cell CLL/lymphoma 7 Protein Family Member C, BCL7C)

Antibodies / Antibodies-Apoptosis

-20°C

Supplied as a liquid PBS,  0.1% sodium azide,  50% glycerol.

Recombinant full length Human BCL7C.

Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-7c (B-cell CLL/lymphoma 7 protein family member C) is a 217 amino acid anti-apoptotic protein that shares 90% sequence similarity to Bcl-7a. Knockdown of IL-10 mRNA induces apoptosis and leads to significant down-regulation of Bcl-7c, suggesting that a modulatory relationship exists between the two proteins. The gene encoding Bcl-7c maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn’s disease, which is a gastrointestinal inflammatory condition. There are two isoforms of Bcl-7c that are produced as a result of alternative splicing events.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.