IRF8 (H ICSBP,H-ICSBP,HGNC:5358,HGNC5358,HICSBP,ICSBP 1,ICSBP,ICSBP1,ICSBP1,Interferon Consensus Sequence Binding Protein 1,Interferon consensus Sequence Binding Protein,Interferon consensus Sequence-Binding Protein,Inte

Antibodies / Antibodies-Interferon

-20°C

Supplied as a liquid PBS,  0.1% sodium azide,  50% glycerol.

Recombinant full length Human IRF8.

ICSBP (Interferon (IFN) consensus sequence-binding protein, Interferon regulatory factor 8; IRF-8) is a transcription factor that is important for IFN-y-mediated signaling during dendritic cell and macrophage differentiation. ICSBP physically interacts with TRAF6 (between amino acid residues 356 and 305), and this interaction of ICSBP with TRAF6 modulates TLR signaling and may contribute to the cross-talk between IFN-y and TLR signal pathways. ICSBP antagonizes Bcr/Abl by downregulation of Bcl-2. ICSBP is known to interact with chromatin, and bind PU.1 in macrophages. ICSBP belongs to the IFN regulatory factor (IRF) family that also includes IRF-1, IRF-2, and ISGF-3. These proteins are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of IFN-alpha and IFN-beta.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.