JIK (Serine/threonine-Protein Kinase TAO3,Cutaneous T-Cell lymphoma-Associated Antigen HD-CL-09,CTCL-Associated Antigen HD-CL-09,Dendritic Cell-derived Protein Kinase,JNK/SAPK-Inhibitory Kinase,Jun Kinase-Inhibitory Kina

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.

Synthetic peptide corresponding to amino acids 540-589 of Human JIK.

JNK/SAPK-inhibitory kinase (JIK) is a serine/threonine kinase that belongs to the STE20 kinase family. The kinase domain of JIK is similar to the GCK-like subfamily of STE20 kinases, while its non-catalytic domain is similar to a Caenorhabditis elegans putative serine/threonine kinase, SULU. JIK inhibits c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK), which is activated by many types of cellular stresses and extracellular signals. JNK/SAPK regulates cell survival, apoptosis and proliferation in mouse development. JIK is negatively regulated by epidermal growth factor (EGF) and tyrosine kinase receptors. In unstimulated human T cells, JIK is cytoplasmic, whereas in the continuously dividing human T cells of Jurkat lymphoma, JIK is nuclear.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.