SSB (Autoantigen La,La,La Autoantigen,La Autoantigen Homolog,La Protein,La Ribonucleoprotein,La Ribonucleoprotein Domain Family Member 3,LA,LARP3,Lupus La Antigen,Lupus La Protein,Lupus La Protein Homolog,MGC118101,

Antibodies / Antibodies-Binding Proteins

-20°C

Supplied as a liquid PBS, 15mM sodium azide, pH 7.2.

Synthetic peptide corresponding to amino acids 331-380 of Human SSB.

Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

Applications:
Suitable for use in Western Blot, Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.