PINK1, NT (PTEN-induced Kinase, BRPK, PARK6BRPK)

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid in PBS, 0.02% sodium azide.

Peptide corresponding to 16aa near the N-terminal of human PINK1.

The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1). PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2). PINK1 is cleaved by the mitochondrial protease PARL (3). Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4)

Applications:
Suitable for use in ELISA, Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1-2ug/ ml
Optimal dilutions to be determined by the researcher.

Positive Control:
A431 Cell Lysate
Mouse Spleen Tissue Lysate
Rat Spleen Tissue Lysate

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.