ATG16L1 Antibody

ArtNr	ABC-AM1817b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot Autophagy Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB, IHC-P
Clon	54CT27.2.6
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7. Metzger S, et al. Hum Genet, 2010 Oct. PMID 20697744. Plasma membrane contributes to the formation of pre-autophagosomal structures. Ravikumar B, et al. Nat Cell Biol, 2010 Aug. PMID 20639872. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. Cotterill L, et al. Can J Gastroenterol, 2010 May. PMID 20485703. Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas? Wolfkamp SC, et al. Eur J Gastroenterol Hepatol, 2010 Aug. PMID 20395867. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. Gazouli M, et al. World J Gastroenterol, 2010 Apr 14. PMID 20380008.
NCBI	NP_001177195.1,NP_001177196.1,NP_060444.3,NP_110430.5,NP_942593.2
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Autophagy-related protein 16-1,APG16-like 1,ATG16L1,APG16L
Similar products	ATG16L1, APG16L, Autophagy-related protein 16-1, APG16-like 1
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Manufacturer - Category	Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Metabolism; Neuroscience; Autophagy; Autophagy; Regulation of autophagy
Manufacturer - Targets	Purified His-tagged ATG16L1 protein(Fragment) was used to produced this monoclonal antibody.
Bio Background	The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 1 (IBD1). Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Monoclonal
Gene Name	ATG16L1 {ECO:0000303\|PubMed:17200669, ECO:0000312\|HGNC:HGNC:21498}
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	68265
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	WB: 1:60 IHC-P: 1:10~50

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