RIPK1 Antibody (N-term)

Primary Antibodies; Cancer; Cell Biology; Signal Transduction; RIG-l-like Receptor; Toll-Like receptor signaling; SARS druggable targets; SARS CoV2 PPIs; Ub protein ligase binding; Apoptosis; Apoptosis signaling; Necroptosis; Necrosis

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

RB34026

Affinity Purified Rabbit Polyclonal Antibody (Pab)

75931

152-180

WB: 1:1000
IHC-P: 1:10~50