GRM7 Antibody (N-term)

Primary Antibodies; Antibody Collections; Neuroscience; GPCR Antibodies; Druggable G protein-coupled receptors (GPCRs)

L-glutamate is the major excitatory neurotransmitter inthe central nervous system, and it activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptorsthat have been divided into three groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5, and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. Multiple transcript variants encoding differentisoforms have been found for this gene.

RB36657

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide