ENC1 Antibody (C-term)

Synthetic Peptide

DNA damage and/or hyperproliferative signals activate
wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing
cell cycle arrest or apoptosis. Mutations that inactivate p53 occur
in 50% of all tumors. Polyak et al. (1997) [PubMed 9305847] used
serial analysis of gene expression (SAGE) to evaluate cellular mRNA
levels in a colorectal cancer cell line transfected with p53. Of
7, 202 transcripts identified, only 14 were expressed at levels more
than 10-fold higher in p53-expressing cells than in control cells.
Polyak et al. (1997) [PubMed 9305847] termed these genes
'p53-induced genes, ' or PIGs, several of which were predicted to
encode redox-controlling proteins. They noted that reactive oxygen
species (ROS) are potent inducers of apoptosis. Flow cytometric
analysis showed that p53 expression induces ROS production, which
increases as apoptosis progresses under some conditions. The
authors stated that the PIG10 gene, also called ENC1, encodes an
actin-binding protein.

Polyclonal

8507

Affinity Purified Rabbit Polyclonal Antibody (Pab)

ENC1 Antibody (C-term) (Cat. #AP17107b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ENC1 antibody detected the ENC1 protein (arrow).

1:1000

Rabbit Ig

395-423

This ENC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-423 amino acids from the C-terminal region of human ENC1.