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SOX2 Antibody (N-term)

SOX2 Antibody (N-term)

ArtNr	ABC-AP2048D
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IF, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	SOX2, Transcription factor SOX-2
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Primary Accession	P48431
Antigen Type	Synthetic Peptide
Application	WB, IHC-P, IF, FC
Bio Background	The intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
Bio References	Remenyi, A., et al., Genes Dev. 17(16):2048-2059 (2003). Wiebe, M.S., et al., J. Biol. Chem. 278(20):17901-17911 (2003). Fantes, J., et al., Nat. Genet. 33(4):461-463 (2003). Schepers, G.E., et al., Dev. Cell 3(2):167-170 (2002). Kamachi, Y., et al., Trends Genet. 16(4):182-187 (2000).
Clonality	Polyclonal
Clone/Animal Names	RB14026
Gene ID	6657
Gene Name	SOX2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Immunofluorescence analysis of SOX2 Antibody (N-term) (Cat.#AP2048d) in HeLa cells. 0.025 mg/ml primary antibody was followed by Alexa-Fluor-546-conjugated donkey anti-rabbit lgG (H+L). Alexa-Fluor-546 emits orange fluorescence. Blue counterstaining is DAPI.
Type image 1	IF
Dilution image 1	1:10~50
Legend image 2	Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35ug/lane). SOX2(arrow) was detected using the purified Pab.
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	Western blot analysis of SOX2 (arrow) using rabbit polyclonal SOX2 Antibody (N-term) (Cat.#AP2048d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SOX2 gene (Lane 2) (Origene Technologies).
Type image 3	WB
Dilution image 3	1:1000
Legend image 4	Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOX2 antibody (N-term) (Cat.#AP2048d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 4	IHC-P
Dilution image 4	1:10~50
Legend image 5	Flow cytometric analysis of NCI-H292 cells using SOX2 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 5	FC
Dilution image 5	1:10~50
Other Accession	Q6EJB7; O42569; P48432; Q6P0E1; P48430; Q2PG84; P53783; O00570; O57401; Q2Z1R2; Q6DGL6; P54231
Predicted	Zf, C, M, X, Sh
Isotype	Rabbit Ig
Calculated MW	34310
Antigen Region	89-119
Antigen Source	HUMAN
Target/Specificity	This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-119 amino acids from the N-terminal region of human SOX2.
NCBI Accession	NP_003097.1

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Menge: 400 ul

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