IL28RA Antibody (Center)

Crown Antibodies; Primary Antibodies; Antiviral defense; Jak-STAT signaling KEGG

The IFNLR1/IL1RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

RB47814

Purified Rabbit Polyclonal Antibody (Pab)

57653

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Interferon lambda receptor 1, IFN-lambda receptor 1, IFN-lambda-R1, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, CRF2-12, Interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, Likely interleukin or cytokine receptor 2, LICR2, IFNLR1, IL28RA, LICR2