Phospho-AKT1(S129) Antibody

Primary Antibodies; Antibody Collections; Cancer; Cardiovascular; Cell Biology; Immunology; Metabolism; Neuroscience; Signal Transduction; Phospho Antibodies; Toll-Like receptor signaling; B cell receptor signaling; Fc gamma R-mediated phagocytosis; T cell activation; T cell receptor signaling; Chemokine signaling; Inflammation mediated by chemokine and cytokine signaling; Interleukin signaling; Jak-STAT signaling KEGG; Apoptosis; Apoptosis signaling

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

RB25385

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat

HUMAN

DB: 1:500