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LATS1 Antibody (N-term)

LATS1 Antibody (N-term)

ArtNr	ABC-AP7035a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1 {ECO:0000312\|EMBL:AAD168821}
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Primary Accession	O95835
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Bio References	Iida, S., et al., Oncogene 23(31):5266-5274 (2004). Yang, X., et al., Nat. Cell Biol. 6(7):609-617 (2004). Kamikubo, Y., et al., J. Biol. Chem. 278(20):17609-17614 (2003). Hisaoka, M., et al., Lab. Invest. 82(10):1427-1435 (2002). Hirota, T., et al., J. Cell Biol. 149(5):1073-1086 (2000).
Clonality	Polyclonal
Clone/Animal Names	RB3029
Gene ID	9113
Gene Name	LATS1 {ECO:0000312\|EMBL:AAD16882.1}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of anti-LATS1 Antibody (N-term) (Cat.#AP7035a) in K562 cell line lysates (35ug/lane). LATS1 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	126870
Antigen Region	1-30
Antigen Source	HUMAN
Target/Specificity	This LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
NCBI Accession	NP_001257448.1; NP_004681.1

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