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LATS1 Antibody (N-term)

LATS1 Antibody (N-term)

Item no.	ABC-AP7035a
Manufacturer	Abcepta
Amount	400 ul
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Iida, S., et al., Oncogene 23(31):5266-5274 (2004). Yang, X., et al., Nat. Cell Biol. 6(7):609-617 (2004). Kamikubo, Y., et al., J. Biol. Chem. 278(20):17609-17614 (2003). Hisaoka, M., et al., Lab. Invest. 82(10):1427-1435 (2002). Hirota, T., et al., J. Cell Biol. 149(5):1073-1086 (2000).
NCBI	NP_001257448.1,NP_004681.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Serine/threonine-protein kinase LATS1,Large tumor suppressor homolog 1,WARTS protein kinase,h-warts,LATS1 {ECO:0000312\|EMBL:AAD168821}
Similar products	Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase, h-warts, LATS1 {ECO:0000312\|EMBL:AAD168821}
Available
Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Signal Transduction
Manufacturer - Targets	This LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
Bio Background	The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB3029
Gene Name	LATS1 {ECO:0000312\|EMBL:AAD16882.1}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Calculated Molecular Weight	126870
Antigen Source	HUMAN
Antigen Region	1-30
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	WB: 1:1000 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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