SPHK1 Antibody (C-term R414)

Primary Antibodies; Cancer; Metabolism; Signal Transduction; Fc gamma R-mediated phagocytosis

SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 61974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 17343) and serum.

RB15395

Purified Rabbit Polyclonal Antibody (Pab)

42518

313-343

WB: 1:1000
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50