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SPHK1 Antibody (C-term R414)

SPHK1 Antibody (C-term R414)

Item no.	ABC-AP7237b
Manufacturer	Abcepta
Amount	400 ul
Category	Metabolism Cholesterol & Lipid Metabolism Antibodies Flow Cytometry Immunohistochemistry Western Blot Enzymes Fatty Acid Catabolism Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, FC, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Hengst, J.A., et al. Arch. Biochem. Biophys. 494(1):23-31(2010) Jarman, K.E., et al. J. Biol. Chem. 285(1):483-492(2010) Gamble, J.R., et al. Am. J. Pathol. 175(5):2217-2225(2009)
NCBI	NP_001136073.1,NP_001136074.1,NP_068807.2,NP_892010.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Sphingosine kinase 1,SK 1,SPK 1,SPHK1,SPHK,SPK
Similar products	SPHK1, SPK, SPHK, Sphingosine kinase 1, SK 1, SPK 1
Available
Manufacturer - Category	Primary Antibodies; Cancer; Metabolism; Signal Transduction; Fc gamma R-mediated phagocytosis
Manufacturer - Targets	This SPHK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 313-343 amino acids from the C-terminal region of human SPHK1.
Bio Background	SPHK1 is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 61974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 17343) and serum.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB15395
Gene Name	SPHK1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	42518
Antigen Source	HUMAN
Antigen Region	313-343
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	WB: 1:1000 WB: 1:1000 IHC-P: 1:50~100 FC: 1:10~50
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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