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RET Antibody (N-term Q28)

RET Antibody (N-term Q28)

ArtNr	ABC-AP7669c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RET, CDHF12, CDHR16, PTC, RET51, Proto-oncogene tyrosine-protein kinase receptor Ret, Cadherin family member 12, Proto-oncogene c-Ret, Soluble RET kinase fragment, Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
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Primary Accession	P07949
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.
Bio References	Da Silva, A.M., et al., J. Clin. Endocrinol. Metab. 88(11):5438-5443 (2003). McWhinney, S.R., et al., J. Clin. Endocrinol. Metab. 88(10):4911-4916 (2003). D'Alessio, A., et al., Endocrinology 144(10):4298-4305 (2003). Soares, P., et al., Oncogene 22(29):4578-4580 (2003). Punales, M.K., et al., J. Clin. Endocrinol. Metab. 88(6):2644-2649 (2003).
Clonality	Polyclonal
Clone/Animal Names	RB01516
Gene ID	5979
Gene Name	RET (HGNC:9967)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of hRET-G28 (Cat. #AP7669c) in MCF7 cell line lysates (35ug/lane). RET (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Flow cytometric analysis of MCF-7 cells using RET Antibody (N-term Q28) (bottom histogram) compared to a negative control (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Isotype	Rabbit Ig
Calculated MW	124319
Antigen Region	13-44
Antigen Source	HUMAN
Target/Specificity	This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-44 amino acids from the N-terminal region of human RET.
NCBI Accession	NP_065681.1; NP_066124.1

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Menge: 400 ul

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