TEK (TIE2) Antibody (C-term)

Synthetic Peptide

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Polyclonal

7010

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of TEK (arrow) using rabbit polyclonal TEK Antibody (C-term)(Cat.#AP7684a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TEK gene (Lane 2) (Origene Technologies).

1:1000

IHC-P

Formalin-fixed and paraffin-embedded human testis tissue reacted with TEK Antibody (C-term) (Cat.#AP7684a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

1:50~100

B

125830

HUMAN

NP_000450.2