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SEMA3A Antibody (Center)

SEMA3A Antibody (Center)

ArtNr	ABC-AP7760c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Semaphorin-3A, SEMA3A, Semaphorin III, Sema III, SEMAD
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Primary Accession	Q14563
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
Bio References	Narazaki, M., Blood 111 (8), 4126-4136 (2008) Tannemaat, M.R., J. Neurosci. 27 (52), 14260-14264 (2007) Appleton, B.A., EMBO J. 26 (23), 4902-4912 (2007)
Clonality	Polyclonal
Clone/Animal Names	RB14591
Gene ID	10371
Gene Name	SEMA3A
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of SEMA3A Antibody (Center) (Cat. #AP7760c) in CEM cell line lysates (35ug/lane). SEMA3A (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SEMA3A antibody (Center) (Cat.#AP7760c), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	Q63548; O08665; Q90607
Predicted	C, M, Rat
Isotype	Rabbit Ig
Calculated MW	88889
Antigen Region	535-566
Antigen Source	HUMAN
Target/Specificity	This SEMA3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-566 amino acids from the Central region of human SEMA3A.
NCBI Accession	NP_006071.1

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ABC-AP7760c-datasheet.pdf

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