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CAV1 Antibody (N-term)

CAV1 Antibody (N-term)

ArtNr	ABC-AP7767b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Caveolin-1, CAV1, CAV
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Primary Accession	Q03135
Antigen Type	Synthetic Peptide
Application	FC, IHC-P, WB
Bio Background	The scaffolding protein CAV1 is the main component of the caveolae plasma membranes found in most cell types. This protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The CAV1 gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade.
Bio References	Smith, J.L., J. Virol. 82 (19), 9505-9512 (2008) Zhong, Y., J. Neurosci. 28 (31), 7788-7796 (2008) Di Vizio, D., Cell Cycle 7 (14), 2257-2267 (2008) Lee, H., J. Biol. Chem. 276 (37), 35150-35158 (2001) Schlegel, A., J. Biol. Chem. 276 (6), 4398-4408 (2001)
Clonality	Polyclonal
Clone/Animal Names	RB15703
Gene ID	857
Gene Name	CAV1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of anti-CAV1 Antibody (N-term) (Cat.#AP7767b) in A2058 cell line lysates (35ug/lane). CAV1(N-term)(arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CAV1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	CAV1 Antibody (N-term) (Cat. #AP7767b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Other Accession	P41350; Q09YN6; Q6RVA9; P49817; P79132; Q2QLB0; Q6B3Y2
Predicted	B, Hs, M, Pig, Rb, Rat, Sh
Isotype	Rabbit Ig
Calculated MW	20472
Antigen Region	2-30
Antigen Source	HUMAN
Target/Specificity	This CAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-30 amino acids from the N-terminal region of human CAV1.
NCBI Accession	NP_001744.2

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Menge: 400 ul

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