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MEK4 (MAP2K4) Antibody (S257)

MEK4 (MAP2K4) Antibody (S257)

ArtNr	ABC-AP7916D
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MAP2K4, SEK1, Dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, MEK4, MKK4, JNKK, JNKK1, PRKMK4, SERK1, MAP kinase kinase 4, c-Jun N-terminal kinase kinase 1, MAPKK 4, MEK 4, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, SKK1
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Primary Accession	P45985
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Bio References	Robinson, V.L., Mol. Cancer Res. 6 (3), 501-508 (2008) Zhang, H., J. Biol. Chem. 282 (20), 14788-14796 (2007) Salmeron, A., EMBO J. 15 (4), 817-826 (1996)
Clonality	Polyclonal
Clone/Animal Names	RB11276
Gene ID	6416
Gene Name	MAP2K4
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of MAP2K4 (arrow) using rabbit polyclonal MAP2K4 Antibody (S257) (Cat.#AP7916d).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP2K4 gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with MAP2K4 Antibody (S257) (Cat.#AP7916d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	P47809; Q07192; Q9DGR7
Predicted	Zf, X, M
Isotype	Rabbit Ig
Calculated MW	44288
Antigen Region	235-264
Antigen Source	HUMAN
Target/Specificity	This MEK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEK4(MAP2K4).
NCBI Accession	NP_001268364.1; NP_003001.1

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Menge: 400 ul

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