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MEK4 (MAP2K4) Antibody (S257)

MEK4 (MAP2K4) Antibody (S257)

Item no.	ABC-AP7916D
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MAP2K4, SEK1, Dual specificity mitogen-activated protein kinase kinase 4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, MEK4, MKK4, JNKK, JNKK1, PRKMK4, SERK1, MAP kinase kinase 4, c-Jun N-terminal kinase kinase 1, MAPKK 4, MEK 4, Stress-activated protein kinase kinase 1, SAPK kinase 1, SAPKK-1, SAPKK1, SKK1
Available
Primary Accession	P45985
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. MAP2K4 is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
Bio References	Robinson, V.L., Mol. Cancer Res. 6 (3), 501-508 (2008) Zhang, H., J. Biol. Chem. 282 (20), 14788-14796 (2007) Salmeron, A., EMBO J. 15 (4), 817-826 (1996)
Clonality	Polyclonal
Clone/Animal Names	RB11276
Gene ID	6416
Gene Name	MAP2K4
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of MAP2K4 (arrow) using rabbit polyclonal MAP2K4 Antibody (S257) (Cat.#AP7916d).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP2K4 gene (Lane 2) (Origene Technologies).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with MAP2K4 Antibody (S257) (Cat.#AP7916d), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	P47809; Q07192; Q9DGR7
Predicted	Zf, X, M
Isotype	Rabbit Ig
Calculated MW	44288
Antigen Region	235-264
Antigen Source	HUMAN
Target/Specificity	This MEK4(MAP2K4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 amino acids from human MEK4(MAP2K4).
NCBI Accession	NP_001268364.1; NP_003001.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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