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CYP8B1 Antibody (C-term)

CYP8B1 Antibody (C-term)

ArtNr	ABC-AP8787B
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CYP8B1, CYP12, Cytochrome P450 8B1, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, CYPVIIIB1, Sterol 12-alpha-hydroxylase
Lieferbar
Primary Accession	Q9UNU6
Antigen Type	Synthetic Peptide
Application	IHC-P, WB, FC
Bio Background	CYP8B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha, 12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.
Bio References	Zhang, M. et.al., J. Biol. Chem. 276 (45), 41690-41699 (2001) Wang, J., et.al., Histochem. Cell Biol. 123 (4-5), 441-446 (2005)
Clonality	Polyclonal
Clone/Animal Names	RB17098
Gene ID	1582
Gene Name	CYP8B1 {ECO:0000303\|PubMed:10051404, ECO:0000312\|HGNC:HGNC:2653}
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of CYP8B1 Antibody (C-term) (Cat. #AP8787b) in K562 cell line lysates (35ug/lane). CYP8B1 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP8B1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Legend image 3	CYP8B1 Antibody (C-term) (Cat. #AP8787b) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Isotype	Rabbit Ig
Calculated MW	58068
Antigen Region	471-501
Antigen Source	HUMAN
Target/Specificity	This CYP8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-501 amino acids from the C-terminal region of human CYP8B1.
NCBI Accession	NP_004382.2

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Menge: 400 ul

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Lieferung vsl. bis 04.09.2025

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