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AIFM1 Antibody (N-term)

AIFM1 Antibody (N-term)

ArtNr	ABC-AP8910a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Neuroscience Neural Lineage Markers Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Microglia Markers
Typ	Antibody Polyclonal
Applikationen	WB, FC, IF, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	References for protein: 1.Daugas,E., et.al., FASEB J. 14 (5), 729-739 (2000) 2.Schulthess,F.T., et.al., PLoS ONE 4 (2), E4394 (2009) References for U251 cell line: 1. Westermark B.; Pontén J.; Hugosson R. (1973).” Determinants for the establishment of permanent tissue culture lines from human gliomas”. Acta Pathol Microbiol Scand A. 81:791-805. [PMID: 4359449]. 2. Pontén, J.,Westermark B. (1978).” Properties of Human Malignant Glioma Cells in Vitro”. Medical Biology 56: 184-193.[PMID: 359950]. 3. Geng Y.;Kohli L.; Klocke B.J.; Roth K.A.(2010). “Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent”. Neuro Oncol. 12(5): 473–481.[ PMID: 20406898].
NCBI	NP_001124318.1,NP_001124319.1,NP_004199.1,NP_665811.1,NP_665812.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Apoptosis-inducing factor 1,mitochondrial,111-,Programmed cell death protein 8,AIFM1,AIF,PDCD8
Similar products	AIF, AIFM1, PDCD8, mitochondrial, Apoptosis-inducing factor 1, Programmed cell death protein 8, 111-
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Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Immunology; Metabolism; Neuroscience; Apoptosis; Apoptosis signaling; Mitochondrion
Manufacturer - Targets	This AIFM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human AIFM1.
Bio Background	AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this protein induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB22966
Gene Name	AIFM1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Calculated Molecular Weight	66901
Antigen Source	HUMAN
Antigen Region	70-98
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IF: 1:200 IF: 1:200 WB: 1:1000 IHC-P: 1:50~100 FC: 1:10~50
Antigen Type	Synthetic Peptide

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