RIP1 Antibody

RIP1 antibody can be used for detection of RIP1 by immunohistochemistry at 5 - 10 µg/mL.

RIPK1;

RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.

RIPK1

75931

RIP1 Antibody is affinity chromatography purified via peptide column.

RIP1 antibody can be used for detection of RIP1 by immunohistochemistry at 5 - 10 µg/mL.

RIP1 Antibody is supplied in PBS containing 0.02% sodium azide.