Caspase-7 Antibody

Casp-7 antibody can be used for the detection of Caspase-7 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL.

CASP7; Depending on cell lines or tissues used, other cleavage products may be observed.

Caspase-7 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

CASP7 {ECO:0000303|PubMed:9070923, ECO:0000312|HGNC:HGNC:1508}

34277

Caspase-7 Antibody is affinity chromatography purified via peptide column.

Casp-7 antibody can be used for the detection of Caspase-7 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 10 µg/mL.

Caspase-7 Antibody is supplied in PBS containing 0.02% sodium azide.