TRAF2 Antibody

TRAF2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TRAF2.
The immunogen is located within the last 50 amino acids of TRAF2.

TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-κ B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

TRAF2 {ECO:0000303|PubMed:28489822, ECO:0000312|HGNC:HGNC:12032}

55859

TRAF2 Antibody is affinity chromatography purified via peptide column.

TRAF2 antibody can be used for the detection of TRAF2 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL.

TRAF2 Antibody is supplied in PBS containing 0.02% sodium azide.