ULK1 Antibody

ArtNr	ABC-ASC11653
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 2007; 12:209–18. Lee EJ and Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95. Yan J, Kuroyanagi H, Tomemori T, et al. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Oncogene 1999; 18:5850–9. Bach M, Larance M, James DE, et al. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem. J. 2011; 440:283-91.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Category	Primary Antibodies; Cardiovascular; Metabolism; Neuroscience; Signal Transduction; Autophagy; Regulation of autophagy
Manufacturer - Targets	ULK1; Two alternatively spliced transcript variants encoding different isoforms have been identified. ULK1 antibody is predicted to not cross-react with ULK2.
Storage Conditions	ULK1 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	ULK1 Antibody: ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
Clonality	Polyclonal
Gene Name	ULK1 {ECO:0000303\|PubMed:9693035, ECO:0000312\|HGNC:HGNC:12558}
Reactivity	H, M, Rat
Calculated Molecular Weight	112631
Antigen Source	homo sapiens
Purification	ULK1 Antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	ULK1 Antibody can be used for detection of ULK1 by Western blot at 1 µg/mL.
Positive Control	Rat Brain Tissue Lysate
Buffer	ULK1 Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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