ULK1 Antibody

ULK1; Two alternatively spliced transcript variants encoding different isoforms have been identified. ULK1 antibody is predicted to not cross-react with ULK2.

ULK1 Antibody: ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.

ULK1 {ECO:0000303|PubMed:9693035, ECO:0000312|HGNC:HGNC:12558}

112631

ULK1 Antibody is affinity chromatography purified via peptide column.

ULK1 Antibody can be used for detection of ULK1 by Western blot at 1 µg/mL.

ULK1 Antibody is supplied in PBS containing 0.02% sodium azide.