N-RAS Antibody

NRAS; N-RAS antibody is predicted to not cross-react with H-RAS

N-RAS Antibody: Activating mutations and overexpression of classical Ras subfamily members (N-RAS, H-RAS, and K-RAS) have been widely investigated as key events in the development of human cancers. The N-RAS protein shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. N-RAS, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

NRAS

21229

N-RAS Antibody is affinity chromatography purified via peptide column.

N-RAS antibody can be used for detection of N-RAS by Western blot at 0.5 – 1 µg/mL.

N-RAS Antibody is supplied in PBS containing 0.02% sodium azide.