APPBP2 Antibody

ArtNr	ABC-ASC11724
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50. Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403. Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Neuroscience
Manufacturer - Targets	APPBP2; APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.
Storage Conditions	APPBP2 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1). The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2). APPBP2 has been found to be highly expressed in breast cancer (3).
Clonality	Polyclonal
Gene Name	APPBP2 {ECO:0000303\|PubMed:26138980, ECO:0000312\|HGNC:HGNC:622}
Reactivity	H, M, Rat
Calculated Molecular Weight	66853
Antigen Source	homo sapiens
Purification	APPBP2 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 µg/ml. Antibody can also be used for Immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Human Brain Tissue Lysate
Buffer	APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC11724-datasheet.pdf

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Menge: 100 ug

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