PIK3C3 Antibody

ArtNr	ABC-ASC11822
Hersteller	Abcepta
Menge	100 ug
Kategorie	Oncology Antibodies By Cell Type Cell Biology Cell Status Western Blot ELISA Autophagy Cardiovascular Research Myocardial Infarction Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Stopkova P, Saito T, Papolos DF, et al. Identification of PIK3C3 promoter variant associated with bipolar disorder and schizophrenia. Biol. Psychiatry 2004; 55:981-8. Hal BS, Gabernet-Castello C, Voak A, et al. TbVps34, the trypanosome orthologue of Vps34, is required for Golgi complex segregation. J. Biol. Chem. 2006; 281:27600-12. Backer JM. The regulation and function of class III PI3Ks: novel roles for Vps34. Biochem. J. 2008; 410:1-17. Jaber N, Dou Z, Lin RZ, et al. Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 2012; 8:707-8.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Immunology; Metabolism; Signal Transduction; T cell activation; Autophagy; Regulation of autophagy
Manufacturer - Targets	PIK3C3; PIK3C3 antibody is human, mouse and rat reactive.
Storage Conditions	PIK3C3 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	PI 3-kinase p100 (phosphoinositide-3-kinase p100 subunit), also known as hVps34 or PIK3C3 (phosphoinositide-3-kinase class III), is a member of the PI3/PI4-kinase family (1). It is a catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate and ubiquitously expressed with a highest expression in skeletal muscle (1, 2). PIK3C3 is involved in the endosome to lysosome transport and plays important roles in intracellular membrane trafficking and autophagy (3-5).
Clonality	Polyclonal
Gene Name	PIK3C3
Reactivity	H, M, Rat
Calculated Molecular Weight	101549
Antigen Source	homo sapiens
Purification	PIK3C3 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	PIK3C3 antibody can be used for detection of PIK3C3 by Western blot at 1 - 2 µg/ml.
Positive Control	Mouse Small Intestine Tissue Lysate
Buffer	PIK3C3 antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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