CADM3 Antibody

ArtNr	ABC-ASC11856
Hersteller	Abcepta
Menge	100 ug
Kategorie	Neuroscience Targets for Rodent Neurosciences Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Fukuhara H, Kuramochi M, Nobukuni T, et al. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene 2001; 20:5401-7. Takai Y, Mioshi J, Ikeda W, et al. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat. Rev. Mol. Cell Biol. 2008; 9:603-15. Kakunaga S, Ikeda W, Itoh S, et al. Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J. Cell Sci. 2005; 118:1267-77. Raveh S, Gavert N, Spiegel I, et al. The cell adhesion nectin-like (Necl) molecules 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. J. Biol. Biochem. 2009; 108:326-36.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
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Manufacturer - Category	Primary Antibodies; Neuroscience
Manufacturer - Targets	CADM3; CADM3 antibody is human, mouse and rat reactive. At least three isoforms are known to exist; this antibody will only detect the two longest isoforms. CADM3 antibody is predicted to not cross-react with other members of the CADM protein family.
Storage Conditions	CADM3 antibody can be stored at 4? for three months and -20?, stable for up to one year.
Bio Background	Cell adhesion molecule 3 (CADM3) is a member of a family of immunoglobulin-like, calcium-independent cell-cell adhesion molecules (1, 2). CADM3 localizes to non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes and is thought to play an important role in the formation of synapses, axon bundles and myelinated axons (3). Recently, CADM3 has been shown to suppress the growth and tumorigenic ability of colon cancer cells, indicating that it can act as a tumor suppressor (4).
Clonality	Polyclonal
Gene Name	CADM3
Reactivity	H, M, Rat
Calculated Molecular Weight	43300
Antigen Source	homo sapiens
Purification	CADM3 antibody is affinity chromatography purified via peptide column.
Antibody Form	Liquid
Application Notes	CADM3 antibody can be used for detection of CADM3 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Mouse Brain Tissue Lysate
Buffer	CADM3 antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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