Comparison

CADM3 Antibody

Item no. ABC-ASC11856
Manufacturer Abcepta
Amount 100 ug
Category
Type Antibody Primary
Applications WB, IF, ELISA, IHC-P
Specific against other
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Available
Primary Accession
Q8N126
Application
WB, IHC-P, IF, E
Bio Background
Cell adhesion molecule 3 (CADM3) is a member of a family of immunoglobulin-like, calcium-independent cell-cell adhesion molecules (1, 2). CADM3 localizes to non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes and is thought to play an important role in the formation of synapses, axon bundles and myelinated axons (3). Recently, CADM3 has been shown to suppress the growth and tumorigenic ability of colon cancer cells, indicating that it can act as a tumor suppressor (4).
Bio References
Fukuhara H, Kuramochi M, Nobukuni T, et al. Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins. Oncogene 2001; 20:5401-7.
Takai Y, Mioshi J, Ikeda W, et al. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat. Rev. Mol. Cell Biol. 2008; 9:603-15.
Kakunaga S, Ikeda W, Itoh S, et al. Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes. J. Cell Sci. 2005; 118:1267-77.
Raveh S, Gavert N, Spiegel I, et al. The cell adhesion nectin-like (Necl) molecules 1 and 4 suppress the growth and tumorigenic ability of colon cancer cells. J. Biol. Biochem. 2009; 108:326-36.
Clonality
Polyclonal
Gene ID
57863
Gene Name
CADM3
Reactivity
H, M, Rat
Legend image 1
Western blot analysis of CADM3 in mouse brain tissue lysate with CADM3 antibody at (A) 1 and (B) 2 µg/ml.
Type image 1
WB
Legend image 2
Immunohistochemistry of CADM3 in mouse brain tissue with CADM3 antibody at 5 µg/ml.
Type image 2
IHC
Legend image 3
Immunofluorescence of CADM3 in mouse brain tissue with CADM3 antibody at 20 µg/ml.
Type image 3
IF
Other Accession
NP_067012; 11056046
Isotype
IgG
Calculated MW
43300
Antigen Source
homo sapiens
Target/Specificity
CADM3; CADM3 antibody is human, mouse and rat reactive. At least three isoforms are known to exist; this antibody will only detect the two longest isoforms. CADM3 antibody is predicted to not cross-react with other members of the CADM protein family.
Purification
CADM3 antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage
CADM3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form
Liquid
Application Notes
CADM3 antibody can be used for detection of CADM3 by Western blot at 1 - 2 µg/ml. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control
Mouse Brain Tissue Lysate;
Buffer
CADM3 antibody is supplied in PBS containing 0.02% sodium azide.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

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