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S100A6 Antibody (monoclonal) (M16)

S100A6 Antibody (monoclonal) (M16)

ArtNr	ABC-AT3760a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, ELISA
Clon	6D1
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	S100A6, CACY, PRA, S100 calcium-binding protein A6, Calcyclin, Prolactin receptor-associated protein, Protein S100-A6, Growth factor-inducible protein 2A9, MLN 4
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Primary Accession	P06703
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.
Bio References	1.Cancer-Initiating Cells from Colorectal Cancer Patients Escape from T Cell-Mediated Immunosurveillance In Vitro through Membrane-Bound IL-4.Volonte A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, Bissolati M, Ghirardelli L, Orsenigo E, Ferrone S, Doglioni C, Stassi G, Dellabona P, Staudacher C, Parmiani G, Maccalli CJ Immunol. 2013 Nov 25.2.S100A6 Overexpression Associates with Poor Prognosis and Is Epigenetically Up-Regulated in Gastric Cancer.Wang XH, Zhang LH, Zhong XY, Xing XF, Liu YQ, Niu ZJ, Peng Y, Du H, Zhang GG, Hu Y, Liu N, Zhu YB, Ge SH, Zhao W, Lu AP, Li JY, Ji JF.Am J Pathol. 2010 Jun 25. [Epub ahead of print]3.Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients.Di Tomaso T, Mazzoleni S, Wang E, Sovena G, Clavenna D, Franzin A, Mortini P, Ferrone S, Doglioni C, Marincola FM, Galli R, Parmiani G, Maccalli C.Clin Cancer Res. 2010 Feb 1; 16(3):800-13. Epub 2010 Jan 26.
Clonality	Monoclonal
Gene ID	6277
Gene Name	S100A6
Subtitle	Mouse monoclonal antibody raised against a partial recombinant S100A6.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33.77 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	S100A6 monoclonal antibody (M16), clone 6D1 Western Blot analysis of S100A6 expression in HeLa ( (Cat # AT3760a )
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western Blot analysis of S100A6 expression in transfected 293T cell line by S100A6 monoclonal antibody (M16), clone 6D1. Lane 1: S100A6 transfected lysate(10.2 KDa). Lane 2: Non-transfected lysate.
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Detection limit for recombinant GST tagged S100A6 is approximately 0.03ng/ml as a capture antibody.
Type image 4	E
Other Accession	NM_014624
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	S100A6 (NP_055439, 18 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_055439.1
	Clone: 6D1
Org Accession	NP_055439
Gene Description	S100 calcium binding protein A6
Gene Summary	The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq

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