Anti-alpha1D-Adrenoceptor (ext.)

IC, IF, IFC, IHC, LCI, WB

Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, ADRA1D

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, ADRA1D - A Rabbit Polyclonal Antibody to α1D-Adrenergic Receptor

Rat, human, mouse - 14/15 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

3rd extracellular loop

Rat

41116161

Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31, 2. The adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1, 2. α1-Adrenergic receptors play an important role in the physiological response to epinephrine and norepinephrine, particularly in the cardiovascular system. All three cloned α1 receptors (α1A, α1B, and α1D) couple to Gq/11. While their cellular distribution is clear, their functional role is less so due to a lack of specific agonists/antagonists3. As these receptors lack specific agonists/antagonists, knock-out (KO) studies in mice have shed significant light on their cellular role. Individual α1-adrenoceptor KO mice do not display physical abnormalities in general. Similar KO studies indicate that all α1 subtypes seem to be involved in the regulation of blood pressure3. Also, studies indicate that α1D-adrenoceptor seems to play an important role in aortic contraction4, renal function, nociception, basal locomotor activity3 as well as bladder contraction5.